Lovastatin Technology

1. Product Presentation

Generic name (USAN)- LOVASTATIN,

Trade names: Mevacor; Mevinacor;...

Trivial names: Mevinolin, Monacolin K, 3-Methyl Compactin.

Empirical formula C24H36O5,  Molecular Weight: 404,55

By additional methylisation Lovastatin can be transferred into Simvastatin.

2. Use

Coronary artery disease is an exceptional important problem in industrial society and is often associated with atherosclerosis, a condition in which esterified and free cholesterol is deposited in thinner walls of coronary arteries. Extensive epidemiological studies have established a link  between abnormally high blood levels of low density lipoprotein cholesterol and the incidence of coronary atherosclerosis.

Lovastatin is a prodrug that treat hypercholesterolemia. After oral administration, parent lactone is hydrolyzed to the corresponding hydroxyacid form.

The hydroxyacid is the principle metabolite and a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase. This enzyme catalyzes the conversion of hydroxymethylglutarate to mevanolate, which is an early and rate limiting step in the biosynthesis of cholesterol

3. Technology

Strain and technological know-how is available

Final titre (expected) 12 ± 1 g/l

Fermentation time 288 ± 24 hrs

Recovery yield 70 ± 5 % 

4. Contact 

Add:    Room 701B/D, Building B, Science Park Tower, Tsinghua Science Park, Haidian District, Beijing 100084, China

Tel:    +86 10 62795180

Fax:    +86 10 62795182 

E-mail:  biotech@ittc.com.cn 

Website: www.coway.com.cn    www.coway-biotech.com