Fermentation Technology to Produce Sirolimus
1. Product Presentation
Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. A macrolide, sirolimus was first discovered as a product of the bacterium Streptomyces hygroscopicus in a soil sample from Easter Island — an island also known as “Rapa Nui”, hence the name.
Molecular weight: 914.9
Empirical formula: C51H79NO13
2. Technology
Strain and technological know-how for fermentation and recovery is available through ITTC:
Strain: Streptomyces hygroscopicus
Final titre: 1.2±0.2 g/L
Fermentation time: 192±24 hrs
Recovery yield: 40%
3. Contact us
Add: Room 701B/D, Building B, Science Park Tower, Tsinghua Science Park, Haidian District, Beijing 100084, China
Tel: +86 10 62795180
Fax: +86 10 62795182
E-mail: biotech@ittc.com.cn
Website: www.coway.com.cn www.coway-biotech.com