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A40926 (Precursor of Dalbavancin)

Final titre: 450mg/L

Fermentation time: 216±12 hrs

Recovery yield: 45%- 55%

 

Pneumocandin B0

Final titre: 1.0-1.2 g/L

Fermentation time: 168 h

Recovery yield: 35% (purity >97.5%)

 

Caspofungin

Caspofungin is synthesized from pneumocandin B0

 

Anidulafungin

Echinocandin B fermentation technology: 200mg/l

Biotransformation  rate: >85%

Purification of Echinocandin B Core: DSP > 70%

Chemical modification of Echinocandin B Core into Anidulafungin: semisynthesis and DSP overall yield > 70%

Anidulafungin overall yield > 40%

 

Daptomycin

Final titer: 2.2±0.2 g/L

Fermentation time: 196±24 hrs.

Recovery yield: ≥40% 

 

Daunorubicin

Final titre (expected): 3±0.3 g/lt

Fermentatiion time: 168±12 hrs

Recovery yield: 67%

 

Capreomycin

Final titre: 8000mg/L

Fermentation time: 158 hrs

Recovery yield: 75%

 

Ramoplanin

Final titre: 2±0.2 g/L

Fermentation time: 216±12 hrs

Recovery yield: > 50%

 

Teicoplanin

Final titre: 5±0.5 g/l 

Fermentation time: 168±12 hrs

Recovery yield: 55%

 

Kanamycin

Titre: 30 g/l

Fermentation Time: 300 hrs

Recovery yield: 80%

 

Sirolimus

Final titre: 1.2±0.2 g/L

Fermentation time: 192±24 hrs

Recovery yield: 40%

 

Tacrolimus

Fermentation titre: 1.5±0.1 g/l

Fermentation time: 240±24hrs

Recovery yield: >70%

 

Cyclosporine A

Final titre: 10±1 g/lt 

Fermentation time: 168 hrs

Recovery yield: 70%

 

Rh- Lactoferrin

Final titre: 3.5±0.3g/L

Fermentation time:  168±12hr

Recovery yield: 60±5%

 

Acarbose

Final titre: 7-9g/lt

Fermentation time: 168±24hrs

Recovery yield: 55%

 

SAMe

Fermentation time:16hrs

Final titre:  10g/L

Extract yield: >50%

 

Coenzyme Q10

Final Titre: 3.5±0.5g/L

Fermentation time: 120±12hr

Recovery yield: ≥50%

 

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